A number of clinical studies established that GHK-CU stimulates the synthesis of collagen, the production of selected glycosaminoglycans (like hyaluronic acid), and modulates matrix metalloproteinases (MMPs)
Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin
Subsequent research revealed that GHK has exceptionally high binding affinity for copper ions (Cu), forming a stable chelate complex (GHK-Cu) that is the biologically active form responsible for the peptide's remarkable effects
10.4161/cc.8.23.10068 Cell Cycle
In pulmonary fibrosis studies using bleomycin to induce lung injury in mice, GHK-Cu doses of 0.0026 to 0.26 mg/mL/day administered every other day reduced inflammatory cell infiltration, decreased interstitial thickness (the scarring that stiffens lung tissue), and lowered TNF-alpha and IL-6 expression
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