Although glutamate is the major downstream product of glutamine, glutamate supplementation during glutamine deprivation cannot rescue the impaired cell growth or mitochondrial respiration 16,43,44,45 , indicating that mitochondrial GLS-catalyzed cleavage of the gamma-nitrogen of glutamine is essential for glutaminolysis
In combinational approach with Al + SeNP-MT 13 , the maximum reduction of Evans blue uptake was obtained by Al + SeNP-MT 2 with 48.23%
BPC-157 Body Protection Compound-157 has been extensively studied for its role in angiogenesis (new blood vessel formation), growth factor modulation, and connective tissue repair
Given the decrease in GPx3 that we observe in konzo affected children, a deeper investigation of possible genetic predispositions is thus warranted, as this has also been a long-standing theory within the research community
A 2023 study in Nature Metabolism showed that GIPR agonism in adipose reduces circulating free fatty acids and improves insulin signaling in muscle, effects that pure GLP-1 agonists produce only weakly [8]
Strasser A, Dedoyard A, Lohninger A & Niedermller H 2007
