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Several factors affect mitochondrial function, including excess reactive oxygen species (ROS)-induced mutations in mitochondrial DNA (mtDNA), changes in mtDNA copy number, oxidative stress (OS), damage to key cellular components and organelles, and changes in metabolic intermediates and byproducts at the cellular level, further affecting oocyte developmental competence

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Histological examination Upon sacrifice, a small piece of liver tissue from each animal was collected and fixed immediately in 10% neutral buffered formalin

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