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Glucagonlike peptide 1 analogue prevents cholesterol gallstone formation by modulating intestinal farnesoid X receptor activity

Appetite suppression is both a therapeutic effect and a potential challenge

According to the FDA's press release it agreed to approve the drug for obesity based on three randomised, double-blind, placebo-controlled trials during which more than 2,600 patients received Wegovy for up to 68 weeks and more than 1,500 patients received placebo (US FDA 2021)

Residual unreacted HSA was removed by three consecutive pulses of 9 s with 25 mM NaOH (3 l), resulting in a surface of 14,360 RFU

That is what is on the line every single time someone loses access to this medication

Like any medication, GLP-1 injections can have side effects, though most are mild and temporary