Glucagon, the ligand of GCGR, increases insulin secretion via GCGR and GLP-1R in pancreatic cells, although GLP-1R is the main insulin-promoting receptor
Medications for Nausea and Vomiting (OTC: Over-the-Counter) Meclizine (Bonine) OTC at low doses (25mg), prescription for higher doses (50 mg or more) Dimenhydrinate (Dramamine) OTC Nauzene-OTC Pepto-Bismol-OTC Dramanine-OTC Emetrol OTC Ondansetron (Zofran) by prescription (check with your doctor, it can cause constipation, a GLP-1 side effect) Metoclopramide (Reglan for GERD) by prescription (check with your doctor, it is used to treat gastroparesis which means it increases gastric emptying
Lyophilized powder should be kept in a freezer at -20C
Dose escalation proceeds in steps to minimize nausea and gastrointestinal side effects while building toward the target maintenance dose
And in the brain, it crosses the blood-brain barrier and activates anorexigenic neurons in the hypothalamus, specifically the POMC/CART pathways that signal fullness while suppressing the NPY/AgRP pathways that drive hunger
Check each item off before you leave the house
