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Malabsorptive procedures (e.g., RYGB, BPD) significantly reduce absorption areas by bypassing the jejunum or ileum, leading to more severe nutrient deficiencies and bone loss

Additionally, it shields body cells from oxidative stress, thereby slowing down the process of cell aging

Dempster WS, Sive AA, Rosseau S, Malan H, Heese HV

Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins

When at least one neuropsychiatric drug (such as antipsychotics, antidepressants, and anxiolytics) was recorded in the report, the patient was defined to have a medication history