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Severe vitamin E deficiency results mainly in neurological symptoms, including impaired balance and coordination (ataxia), injury to the sensory nerves (peripheral neuropathy), muscle weakness (myopathy), and damage to the retina of the eye (pigmented retinopathy)

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Potential for cardiovascular benefits: Preliminary research suggests that retatrutide may improve cardiovascular risk factors, such as blood pressure and cholesterol

The main practical concern is increased injection burden and harder attribution if new side effects appear