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They work together in a cycle: when glutathione neutralizes a free radical, it becomes "spent" or oxidized

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Performance of a portable whole-body mouse exposure system

doi: 10.1016/j.jaut.2017.07.007 104

Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions

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