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Both systemic injection (intramuscular) and local application (directly at the bone defect) produced healing improvements

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J Biol Chem 271:81018107 Becker K, Christopherson RI, Cowden WB, Hunt NH, Schirmer RH (1990) Flavin analogues with antimalarial activity as glutathione reductase inhibitors

The ability of a phagocyte to perform multiple rounds of phagocytosis of ACs in a relatively short timecalled continuous efferocytosisis essential in scenarios where the ACs:phagocytes ratio is high, such as after an acute inflammatory process or tissue injury

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