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FDA-approved for three indications with multiple active-comparator trials, cardiovascular outcomes data, and extensive post-marketing surveillance

For example, a small study found oral glutathione (300 mg/day for 4 months) improved enzyme / bilirubin levels in non-alcoholic fatty liver disease (MASLD) patients

These drugs are known to cause extreme nausea, vomiting, diarrhea, and gastroparesis

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In some cases, coverage may be limited based on BMI criteria, leaving some patients unable to obtain the medication through their insurance plan