No impact on bone fractures : If osteoporosis is a concern, the GLP-1 receptor agonists were shown not to increase fracture rates.[ref] Benefits for CVD : In a huge cardiovascular disease study, GLP-1 RAs were shown to be associated with a lower risk of heart attacks and strokes.[ref] Works best with Exercise: A randomized clinical trial found that GLP-1 RAs work best for weight loss when combined with exercise
A clinical trial for diabetes that pit orforglipron, a diabetes and weight-loss pill developed by Eli Lilly, against oral semaglutide, made by Novo Nordisk, suggests the former pill may have the edge in reducing blood sugar and weight
However, despite their effectiveness in rodent B cells, these agents do not induce the same proliferative response in human beta cells
Place your elbows on your thighs
The strongest interpretation is that formulation, route, condition, and study design determine how much confidence a claim deserves
Healthier hair, skin, and nails : Promotes healthy hair growth and improves the appearance of skin and nails