If methotrexate plus glucocorticoid is insufficient, any bDMARDs or tsDMARDs can be recommended to add to csDMARDs, such as methotrexate plus tocilizumab, methotrexate plus rituximab, methotrexate plus tofacitinib, and so on (15)
L. I. Fedoreyeva, T. A. Smirnova, G. Ya. Kolomijtseva, V. Kh. Khavinson, and B. F. Vanyushin, Interaction of short peptides with FITC-labeled wheat histones and their complexes with deoxyribooligonucleotides, Pleiades Publishing Ltd, Feb. 2013. doi: 10.1134/s0006297913020053
Decreased clearance of CNS beta-amyloid in alzheimer's disease
When administered by a trained healthcare provider, peptide therapy is considered safe for extended use and may even support anti-aging and regenerative health goals.

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When administered therapeutically, they can stimulate the pituitary gland, hypothalamus, and other endocrine organs to increase their natural hormone output