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Recent efforts by the World Small Animal Veterinary Association (WSAVA) Gastrointestinal Standardization Group have led to both diagnostic and classification guidelines35, 168, 169 that encompass chronicity, nonresponse to symptomatic treatment, no specific cause found, as well as histologic confirmation of non-neoplastic intestinal inflammatory changes

Acute catabolic disorders may occur when infections are present

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For instance, the development of autoimmune diseases is stimulated by iodine (excess or deficiency), smoking, stress, and chemical contaminants (like polyaromatic hydrocarbons), medicine (like amiodarone and interferon-alpha (IFN), and bacterial and viral infections (like hepatitis C virus and Yersinia enterocolitica)