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Limitations of the RCTs include that most often there are a low number of participants: the studies described here had fewer than 100 study subjects, with the exception of the PREDIMED trial studies

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Hence, we strongly encourage the adoption of GLP-1RA plus SGLT2i combination therapy in T2DM patients with uncontrolled metabolic risks, i.e., especially those who need to lose weight and/or control high blood pressure

Its important to understand that an elevated prolactin level is not always due to a prolactinoma

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