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ALTERATIONS IN GLUTATHIONE PEROXIDASE AND SUPEROXIDE DISMUTASE ACTIVITIES IN PLASMA AND SALIVA IN RELATION TO DISEASE ACTIVITY IN PATIENTS WITH CROHN'S DISEASE INTRODUCTION Crohn's disease (CD) is a chronic inflammatory disorder of the entire gastrointestinal (GI) tract, which most commonly affects the terminal ileum and proximal colon (1-3)

doi: 10.1007/s10067-014-2517-2

In general, these hypotheses present the assumption that microbiota of proper composition regulates epithelial barrier function, including by regulating barrier permeability and TJ, influencing vascular permeability and angiogenesis, and affecting local inflammation and GALT tolerance [1, 55, 56]

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17, 20S (OH) 2pD can prevent the development of skin fibrosis in the bleomycin-induced scleroderma mouse model