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Furthermore, patients with AP often receive medications (e.g., sedatives, antibiotics, and vasoactive agents) that can influence cytoskeletal organization and mitochondrial function, complicating the clinical applicability of strategies derived from reductionist models

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[24] SCC usually appears on parts of the body most often exposed to the sun such as the head and neck, arms and legs

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On an experimental day, cells were washed with Hanks Balanced Salt Solution (HBSS, Gibco/ThermoFisher Scientific) and the respective receptors were labeled with 100 nM HaloTag NanoBRET 618 ligand (Promega Corporation, Fitchburg, WI) in phenol red-free Opti-MEM I reduced serum medium (Gibco/ThermoFisher Scientific) (2 h, 37 C, 5% CO 2 )

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