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However, these medications do not directly target thyroid function or autoimmune processes, which is an important distinction when considering their potential role in Hashimoto's disease management

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Hepatic clearance accounts for roughly 25% of total apixaban elimination, primarily through CYP3A4 with minor contributions from CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2J2 [2]

Obesity is a key therapeutic area for Pfizer, and we have a robust pipeline with three clinical and several pre-clinical candidates

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However, the higher oral doses compensate for this difference