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Researchers suggest that by targeting different pituitary receptors with the same potential, peptides like Sermorelin and GHRP-2 may have synergistic actions

It is proposed to work by binding GHRH receptors on pituitary somatotroph cells, prompting the pituitary to synthesize and release its own growth hormone in a pulsatile pattern, with the body's somatostatin feedback loop still intact so the effect is self-limiting rather than a constant hormone flood

Hormone-based therapies ranging from GLP-1 drugs to dual and triple agonists now dominate the 2026 obesity drug pipeline

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