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avoid rechallenge if serious outcomes or clear recurrence occurs

Certain populationspregnant individuals, those with thyroid disease history, or specific cardiovascular conditionsmay be ineligible or require specialist clearance

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The longer time to onset of immune-related adverse events in our study underscores the importance of ongoing monitoring of patients during checkpoint inhibitor therapy, because such adverse events can occur at any time, and we found no patient factors that can help to predict their occurrence