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These improvements could be due to numerous reasons

Given that GABA is generally sleep-promoting (Gottesmann, 2002), this suggests a potential behavioral homeostatic feedback loop, with nitrogen stress accumulation during chronic sleep loss promoting the synthesis of Put-GABA, and thus sleep

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The combination of phentermine, a psychostimulant, and topiramate, a carbonic anhydrase inhibitor, has been associated with increased heart rate (Alfaris 2015)

These side effects are usually most noticeable during the first 2 months and improve significantly by weeks 6-8

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