Defining the palliative care patient: a systematic review
Though overall the risk remains low, oral estradiol is associated with increased venous thromboembolism (VTE) risk, whereas transdermal estradiol was not found to be associated with significant increased risk of VTE.7 The reason for the discrepancy is thought to be the result of procoagulant factors being formed as a result of first pass hepatic metabolism for estradiol, a factor that doesnt apply to the transdermal route
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Lykidis A, Chen CL, Tringe SG, McHardy AC, Copeland A, Kyrpides NC, Hugenholtz P, Macarie H, Olmos A, Monroy O, Liu WT (2011) Multiple syntrophic interactions in a terephthalate-degrading methanogenic consortium
There is nothing there about intending to give the dogs pimobendan until they die, or that doing so would "benefit" the dog
A 5mg vial at the 0.25mg starting dose provides 20 weeks of doses, but the solution expires after 4 weeks
