Following a thorough analysis of our previous Phase IIb data and trial design, we are confident that with the preferred modified release formulation and optimized future trial design, we can advance a competitive oral GLP-1 molecule into registration-enabling studies to meet the ongoing medical needs of people living with obesity. The ongoing open-label, randomized study is assessing the pharmacokinetics and safety of immediate- and modified-release formulations of danuglipron administered orally in healthy adults aged 18 years or older
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This lowers the activity of GNMT reducing the effectiveness of the salvage pathway that is one of the homeostatic mechanisms
Mid-cycle blood work at around week 3-4 can identify any concerning trends before they become serious issues