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189 PDZK Polyvalent PDZ domain 1 (PDZK1) is a multidomain protein with four PDZ domains, primarily located at the apical membrane of kidney proximal tubule cells

2016 Jul 18;7(7):CD011694

doi: 10.1126/science.283.5407.1488 35 Martinez-ReyesIChandelNS

Key limitations of current evidence include: Relatively short follow-up periods (typically 35 years) in randomised trials, whereas pancreatic cancer may take years to develop Potential for detection bias, as patients on GLP-1 therapy may undergo more frequent medical monitoring Difficulty accounting for all confounding factors in observational studies Despite these limitations, the weight of current evidence does not support a causal link between GLP-1 receptor agonist use and pancreatic cancer development

Resveratrol may hold promise as a treatment for CKD via modulation of several cellular pathways involved in kidney damage