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Hepatology 49 , 407417 (2009)

(NBER Working Paper 34678), Coady Wing, Sih-Ting Cai, Daniel W

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doi: 10.1017/S0954422410000247

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In MDD, this peripheral-central coupling is likely amplified by BBB dysfunction characterized by increased permeability, neurovascular inflammation, and associations with symptom severity [172, 173] thereby lowering the threshold at which peripheral KP activation translates into central glutamatergic, oxidative, and neuroimmune dysregulation