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Often considered a silent disease, MASH frequently presents no noticeable symptoms until substantial liver damage has already occurred, making early detection through regular screenings vital to prevent further progression and complications

Tirzepatide's binding kinetics at GLP-1R result in lower beta-arrestin recruitment relative to cAMP generation, a biased agonism profile, which may partly explain the sustained glucose-lowering effect observed across 40 weeks in SURPASS-2 [19]

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