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So if you have a frail older individual who maybe doesn't have much weight to lose, already has lost muscle mass, and you put them on this medication, you could be asking for trouble

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(See Figure 2 for a timeline of key activities associated with the GLP-1 coverage demonstrations.) Medicare coverage of GLP-1s for obesity begins in July 2026 through the Medicare GLP-1 Bridge and will be extended through the end of 2027 CMS will provide Part D beneficiaries with coverage of select GLP-1s for obesity from July 1, 2026 to December 31, 2027 (originally December 31, 2026) through the Medicare GLP-1 Bridge, which is a short-term demonstration established using Section 402 demonstration authority

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Once bound to the antioxidant response element (ARE), Nrf2 upregulates cytoprotective genes such as Heme Oxygenase-1 (HO-1) and NAD(P)H: Quinone Oxidoreductase 1 (NQO1) (Kim et al., 2017

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