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According to Life Extension's Dr

Since I carry the COMT and MTHFR variants, that means I have more difficulty in methylation and risk buildup of harmful estrogen forms

Aggregation This is perhaps the most dangerous degradation pathway

Studies demonstrate that BAs attenuate lipopolysaccharide (LPS)-induced upregulation of NLRP3, ASC, and Caspase-1, thereby reducing MPO activity, inhibit neutrophil infiltration, and alleviate inflammatory responses (43)

By supplying a direct, ready-to-use pool of Acetyl-CoA, ALCAR bypasses several rate-limiting steps in cellular metabolism

It helps regulate the immune response and supports the activity of T-cells, which play a crucial role in the body's defense against pathogens