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10.1074/jbc.M403832200 70 SjlinderM.TornhamreS.ClaessonH

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Activation of the adipocyte CREB/CRTC pathway in obesity

The latter one which included 4 trials (43,456 patients) suggested that GLP-1 RAs reduced MACE by 13% (HR 0.87, 95% CI 0.820.93), an effect which was consistent in both subgroups (HR 0.91, 95% CI 0.850.97 and HR 0.80, 95% CI 0.720.90 with and without metformin, respectively)

III Glutathione peroxidase GPx the oxidising enzyme A selenium-containing enzyme family that converts GSH to GSSG