Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KS, Xu A
According to meta-analysis data, hypothyroidism occurs in about 3.8% of patients treated with anti-CTLA-4, 3.9% with anti-PD-L1, 7.0% with anti-PD-1, and 13.2% with combination therapy
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The safest protocol is to discard the vial
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Under hypoxia, the mitochondrial ETC is inhibited, and energy synthesis and Asp synthesis are limited, which leads to the dependence of tumor cells on the environmental uptake of Asp