considerations for trainers coaching glp-1 therapy Nutritional priorities to support obesity: A joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and the Obesity Society Transforming Care: Implications of Glucagon

doi: 10.1016/j.marpolbul.2021.112059 3 BourboulouxA.ShahiP.ChakladarA.DelrotS.BachhawatA

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PubMed PMID: 10734331

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Additionally, dehydration resulting from gastrointestinal side effects may contribute to muscle cramping and joint stiffness

GLP-1 RAs Hold Promising Potential for Reduction of Cardiometabolic Risk Factors additional benefits : Brain: Appetite suppression, nerve protection, and decreased neuroinflammation Heart: Decreased blood pressure (systolic and diastolic), reduced total cholesterol levels, lowered endothelial dysfunction, and increased heart rate Liver: Decreased glucose production Pancreas: Increased insulin secretion, decreased glucagon secretion, B islet cell proliferation GI Tract: Decreased gastric emptying Because these drugs cause weight loss, it is not clear whether the GLP-1 RAs or the weight loss reduces cardiometabolic risks