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The reconstituted solution is reliably usable for approximately 24 hours after which, for research purposes, the solution should be discarded

Given that GSH is essential for cellular redox reactions and the processing of ROS, evidence points to an impaired antioxidant defense in ME/CFS (Rae and Williams, 2017)

Cell Metabolism , 21(3), 443-454

Yes, it's something additional to do, but highly necessary in a global, fragmented supply chain with what I would consider minimal barriers to entry for health-implicating products

The FDA's Pharmacy Compounding Advisory Committee reviewed AOD-9604 in December 2024 and recommended against permitting its use in 503A pharmacy compounding

The benefit comes from replacing whats missing, not from extra B12 on top of normal levels