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People with active, untreated hyperthyroidism should stabilize their thyroid condition before starting weight loss treatment

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The majority of serotonin in the body is produced and used in the gut from its precursor tryptophan

Risk of bias, certainty of evidence, and consistency The risk of bias for each trial is shown in appendix 4

In particular, for patients who do not respond to conventional therapies, the regulatory mechanisms of the BGA may represent important intervention targets (Figure 1)