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Different from the dipped down side chain conformation observed in GLP-1-bound GLP-1R 27 , F257 3.60b in the peptide 20GLP-1RG s complex rotated its side chain upwards (Fig
These include promoting short-chain fatty acid (SCFA) production, reshaping microbial diversity and community composition, and inducing functional shifts in microbial metabolism, particularly SCFA-related and other energy-regulating pathways
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Glutamatergic excess can result in neurotoxic oxidative stress [28], while a concomitant elevation of GSH may provide a neuroprotective gate-keeping effect [29], thus a strong covariance may be a marker of a healthy state
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