semaglutide vs tirzepatide comparison caused roughly half as many patients to stop treatment because of gastrointestinal side effects as semaglutide. In the first major head-to-head obesity trial, GI side effects caused treatment discontinuation in: Tirzepatide Semaglutide vs. Tirzepatide: Which GLP-1

doi:10.1093/humupd/dmq003

A recent Nature publication further showed that a bimodal molecule combining GLP-1 receptor agonism with NMDA receptor antagonism could reverse obesity and hyperglycaemia in rodent models, with targeted effects on hypothalamic and brainstem neuroplasticity (Petersen et al., 2024, DOI)

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