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Common Side Effects of Semaglutide Semaglutide is generally safe when used under medical supervision, but like all medications, it can cause side effects

That differs from prescription GLP-1 receptor agonists, which change gut-brain hormone signaling and alter appetite regulation centrally

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Titration Gradual dose increase over 16 weeks to minimize side effects Side Effects Common Side Effects Most side effects are mild and improve as your body adjusts to the medication