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Los estudios SURPASS en diabetes tipo 2 demostraron reducciones significativas en la hemoglobina A1c (hasta 2.0-2.5% en dosis ms altas), mientras que los estudios SURMOUNT en obesidad evidenciaron prdida de peso sustancial (promedio de 15-21% del peso corporal a las 72 semanas) con administracin semanal flexible

sex was not considered as a biological variable

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From an investor perspective, REMS drugs carry lower addressable market than their clinical profile might suggest, and REMS modifications either adding or removing requirements can materially affect commercial execution