People across all weight categories showed similar rates of nausea, diarrhea, and other gastrointestinal symptoms
doi: 10.1080/13825580600788100
J Am Soc Nephrol 22(11):19811989
Your prescriber may recommend: Temporarily maintaining your current dose for an additional week or two before escalating, allowing more time for adaptation Anti-emetic medication for severe nausea (such as domperidone or metoclopramide, which should only be used short-term and under medical supervision due to potential side effects) Laxatives for constipation or anti-diarrhoeal agents for persistent diarrhoea Dose reduction or treatment discontinuation if side effects remain intolerable despite supportive measures Seek urgent medical attention if you experience severe abdominal pain (particularly if radiating to the back), persistent vomiting preventing fluid intake, signs of pancreatitis, or symptoms of gallbladder disease
Implementing a cycling schedule (5 days on, 2 off, or 3 weeks on, 1 week off) prevents tolerance and maintains receptor responsiveness
Eating disorder, low protein intake
