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NACP/alph-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains

It does not appear on the list of controlled substances, but its sale as a dietary supplement or health product is not authorized

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FPN is regulated by hepcidin, a hepatic-secreted peptide hormone, which promotes the internalization and degradation of FPN [74]

doi: 10.3389/fnins.2020.00494 42 NiethammerM.TangC

A peptide injected into systemic circulation faces rapid enzymatic degradation there, which is a real pharmacokinetic cost that "bypasses the barrier" framing tends to leave out entirely