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In all three neuronal clusters, we found a similar pattern of gene expression changes after treatment with the GIPR antagonist and acyl-GLP-1, with 29 genes in the C35 Glut10 cluster, 29 genes in the C35 GABA4 cluster and 45 genes in the C35 GABA3 cluster affected by both GLP-1R agonism and GIPR antagonism (Fig

90% men), all of whom had diabetes and took either a GLP-1, such as semaglutide (Ozempic) or tirzepatide (Mounjaro), or an older diabetes drug called an SGLT-2, such as empagliflozin (Jardiance)

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It helps to collect all the needed information, like how much levothyroxine you took and the last time you had a dose

PMID: 31383735