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doi: 10.1111/j.1420-9101.2009.01809.x Summary Keywords appendectomy, appendicitis, colorectal cancer, Mendelian randomization, risk Citation Wei W, Wang J, Yu D, Liu W and Zong L (2024) Appendectomy and appendicitis do not increase colorectal cancer risk: evidence from Mendelian randomization

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130 With this varied evidence, metformin has shown its antiproliferative activity in the cancer cell lines which can prove instrumental in cancer management but the concentration at which these effects are demonstrated are quite high as compared to the therapeutic levels in plasma and can prove toxic for humans so studies with improved protocols with lower concentration need to be tested in future to establish its effective anticancer property in clinical subjects

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