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SURMOUNT-1 (NEJM 2022) showed 22.5% mean weight loss at 72 weeks on the 15 mg dose
Called orforglipron, its part of a growing class of drugs known as GLP-1s, which include Novo Nordisks Ozempic and Wegovy
The Science Behind the Fat-Loss Shot Stack Researchers are now exploring the potential synergy between Retatrutide + Cagrilintide, combining GLP-1/GIP/glucagon activation with amylin signaling for multi-pathway fat loss
Weight loss, achieved through a combination of diet, exercise, and lifestyle changes, can help improve GLP-1 levels and insulin sensitivity
Both options can be prescribed by licensed clinicians