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Interchangeability requires demonstrating that switching between the reference biologic and the biosimilar produces no greater safety or efficacy risk than remaining on the reference product

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The present review examines the multifarious functions of TMAO and betaine with possible molecular mechanisms towards a better understanding of their emerging and diverging functions with probable implications in the prevention, diagnosis, and treatment of human diseases

Black or tarry stool, visible blood in the stool, vomiting blood, severe abdominal pain, unexplained weight loss, persistent fever, anemia, or progressive swallowing difficulty should be evaluated appropriately

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