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Besides, caffeic acid and chlorogenic acid (caffeoylquinic acids) are two other classical phenolic acids widely found in natural plants, both of which are the most vital active substances in coffee [168]

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Moreover, glutathione helps to regenerate other important antioxidants in the body, such as vitamin C and vitamin E, which also play a critical role in neutralizing free radicals and protecting our cells from oxidative stress

Attempts to overcome resistance entail the creation of drugs that hit new targets, which may lead to more adverse effects and a lack of efficacy in the clinical setting [57]