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[26,27,28] Bitter Melon helps regulate blood sugar and weight, and promotes insulin release and uptake

MDW, AG, SMR and AAS acknowledge support from the National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre

Moreover, downregulation of GLP-1R level is also found in the glomerular endothelial cells of diabetic mice, which may be due to increased GLP-1R degradation resulted from diabetes-induced PKC2 activation 28

The Open Field SuperFlex boxes were partitioned into center and perimeter areas and evaluated as an open field test

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