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Comparing adverse-event percentages from separate Wegovy and Zepbound trials can be misleading because study populations, doses, and reporting methods differ

Wolfgang Marik: declares no conflict of interest relevant to this study

Its ability to mimic the hormone glucagon-like peptide-1 (GLP-1) is crucial in regulating appetite and food intake

They all raise GLP-1 to pharmacologic levels that are far above what our bodies make

In a Phase 2a trial, GSBR-1290 resulted in a significant weight loss of 6.2% after 12 weeks, outperforming the placebo group

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