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EMA Statement on Ongoing Review of GLP-1 Receptor Agonists
Neurobiol Aging 28(9):14361445
What we should actually do The path forward is not to ban curiosity or dismiss the underlying science
The goal of this slow progression is to allow the body to adjust to the compounds effects on appetite regulation, gastric emptying, and metabolic signaling while minimizing gastrointestinal discomfort and other tolerability concerns
For example, the peak reduction of the NADP pool coincided with the highest H 2 O 2 levels
Goal: Increase testosterone naturally without TRT Approach: HCG 1500-3000 IU weekly, divided into 3 injections Example: 750 IU Monday, Wednesday, Friday Adjust based on response and symptoms Expected results: Testosterone increase of 40-80% above baseline Symptom improvement in 50-80% of men Maintained fertility Limitations: Ceiling effect, can't achieve supraphysiological levels May not provide adequate testosterone for all men Requires ongoing injections Who should and shouldn't use HCG HCG offers significant benefits for appropriate candidates but isn't suitable for everyone
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