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The FDAs approval is backed by pivotal data from the Phase III OCARINA II trial, which showed no clinically significant difference in levels of Ocrevus in the blood after subcutaneous administration

Aging Cell 13(6):1091

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The co-formulation creates a more robust and impenetrable barrier to DNA synthesis entry, effectively trapping cancer cells in a state where repair is futile and progression is blocked, ultimately committing them to programmed cell death

(2) In the other alternative a leukocyte-rich plasma (LRP), prepared from whole blood by polysucrose-aggregation of the erythrocytes (as described in this Application Sheet), is layered over the density barrier which separates the MCs and PMNs