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Many recent studies also focus on the metabolic aspects of depression, suggesting the involvement of peripheral and central impairments in energy homeostasis, mitochondrial dysfunction, as well as disturbances in the gut-brain axis and gut microbiota dysbiosis as noteworthy factors in the pathogenesis of depression [6,7,8,9]

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A chronic low-grade inflammaging process is accompanied by immunosenescence, i.e., a gradual deterioration of the immune system with aging, especially the functions of adaptive immunity decline [7, 151]

The affinity gel was washed repeatedly with the same buffer before elution of the protein with 20 mM GSH or 20 mM S-hexyl-glutathione in binding/washing buffer

G6PD enzyme level taken on admission was 7.47 U/g Hb (normal, above 6.76 U/g Hb)