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Data availability The cryo-EM maps have been deposited in the Electron Microscopy Data Bank (EMDB) under the accession codes EMD-71735 (OCTN2 inward-facing), EMD-71540 (OCTN2 occluded) and EMD-71597 (OCTN2 ipratropium)

4f), ultimately restoring normoglycemia once therapeutically effective thresholds were reached (Fig