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Their quality or safety may be compromised

10.1038/s41576-019-0183-6 78 MengT.XiaoD.MuhammedA.DengJ.ChenL.HeJ

Early trials with both drugs raised concerns over side-effects with both drugs causing some nausea at administration, sometimes accompanied by headaches and in the case of melanotan II (and early developments of bremelanotide) significantly raised blood pressure in some patients

Administration of peptides with permeation enhancers, which transiently alter epithelial tight junctions to increase permeability, has been the most studied approach

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